Sheldon Cooper: A nine-to-fourteen-year-old math and science genius who struggles with social cues.George Cooper Sr.: Sheldon's father, a high school football coach and a supportive, flawed family man.Mary Cooper: Sheldon's deeply religious and fiercely protective mother.Melissa "Missy" Cooper: Sheldon's sharp, rebellious twin sister who often feels overlooked.George "Georgie" Cooper Jr.: Sheldon's older brother who navigates early fatherhood and business.Connie "Meemaw" Tucker: Sheldon's rebellious, witty, and gambling-loving grandmother.